UNIDIRECTIONAL FREEZING GEOMETRY

The unidirectional freezing geometry, relies on a bottom-up cooling flow, allowing a much higher level of precision and control of the freezing process. As consequence, is possible to reach a much better standard of homogeneity, reproducibility and volume scalability compared to other cryopreservation systems, minimizing the risk of product degradation.

The Cryocube system is a single-use cryopreservation equipment designed for volumes up to 300L incorporating the unidirectional freezing geometry.

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PROTEIN STABILITY MEASUREMENT BELOW 0°C

SmartFreeZ developed a unique method that replicates in a short time frame, the freezing behavior of years  for each substance.  This solution enables to save time, anticipating the lifespan of each molecule, measuring its stability and optimizing its cryopreservation method.

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COMPUTATIONAL FLUID DYNAMICS (CFD)

SmartFreeZ uses advanced computational simulations tools to optimize cryopreservation systems, understanding and designing our customer’s requirements:

  • Freezing geometry
  • Freezing buffer
  • Freezing temperature
  • Nucleation temperature
  • Storage temperature
  • Thawing temperature
  • Agitation and mixing during thawing

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CELL CRYOPRESERVATION

The unidirectional geometry-based method can be applied to the universe of cell cryopreservation, improving its results in terms of homogeneity and reproducibility.

CRYOPRESERVATION OF SPOROZITES (MALARIA PARASITE)

SmartFreeZ has applied the unidirectional freezing geometry to the sporozites cryopreservation, reaching an unprecedented survival rate, contributing to move a step forward in the development of a vaccine for malaria.

 

Freezing Problems Addressed by SmartFreeZ

APPLICATIONS

SmartFreeZ’s computational simulations tools can be applied to several cryopreservation purposes:

Freeze-thawing:  Modelling of freeze-thaw systems to address scale up and scale down challenges.

Small-scale freezing: Modelling of small scale freezing systems using the unidirectional freezing geometry.

Freeze-drying: Modelling of small scale freezing systems using the unidirectional freezing geometry.

Cryopreservation systems design: CFD modelling allows to define the required configuration for the designing and prototyping of tailor-made cryopreservations systems

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If you have any questions, feel free to contact us!