Smartfreez is currently providing Digital-Twins, to anticipate cryopreservation hurdles with minimal experimental testing, to reduce costs and shorten development period of freeze-sensitive molecules.
The Cold Stability Accelerator measures isothermal degradation rates below freezing temperature without freezing the samples, enabling to discern the effect of temperature (by cold denaturation) from the interfacial stresses related to ice.
This system can also be used to anticipate in a short time frame (week) the long-term storage stability, which is relevant for optimization of formulation or cold chain logistics.
This “stress-time” varies across the container; for example, the stress at the walls is different than at the center. The Micro-Scale-Down can convert a 5 mL vial into a representative physical model for freeze-thaw stress in 2L to 20 L manufacturing containers.
Smartfreez Digital-Twins provide an accurate assessment of performance of Smartfreez systems, which can be used to maximize scalability, anticipate hurdles and accelerate time-to-market.