THE PROTEIN STABILITY CHALLENGE
Preventing aggregation of therapeutic proteins during storage is a major challenge for the biopharmaceutical industry because aggregation is highly related to immunogenecity. It is important to understand the protein stability to anticipate aggregation associated to the processing and storage of biotherapeutics.
ACCELERATING THE PROTEIN LIFE CYCLE
Aggregation is usually very slow to be studied thoroughly its practical time, for this reason several methods have been developed to accelerate kinetics by destabilizing the proteins in order to measure protein stability. These methods include temperature increase, adding denaturing chemicals or selecting a convenient pH.
MEASURING STABILITY BELOW 0ºC
SmartFreeZ’s method is the only one that enables the protein aggregation acceleration for temperatures below 0ºC, overcoming technical limitations caused by freezing.
This is an important tool to improve stability and to extend shelf life of protein therapeutics.