NORMABLAST
freeze-thaw systems

A VERSATILE SYSTEM FOR OPTIMAL FREEZING AND THAWING

Our NORMABLAST is a high-performance freeze-transport-thaw system for biologics. It can prevent the increase of pressure during freezing, attenuating cryoconcentration and other mechanical stresses that degrade the biologic substances upon freezing and thawing. We can customize the NORMABLAST to address different capacity, number, size, and type of containers, enabling you to reach optimal freezing and thawing performance for bottles or bags. You can anticipate the performance of the NORMABLAST, or compare it with alternative systems, using the SMARTFREEZSIM digital twins, a cloud-based platform that generates computational fluid dynamics (CFD) simulations.

Normablast Shield for freezing and thawing

one shield suits it all

NORMABLAST Shield is the only single-use system for freezing and thawing, storage and transport of biopharmaceuticals in bottles. It can provide high freeze-thaw consistency by acting as an individual airblast for each bottle. Therefore, it minimizes operator handling during the complete cold chain, ensures optimal quality and efficiency. Is also available a version for bags.

scale-down device - freeze-thaw

SCALE-DOWN Physical MODELS

Our down-scaled system is designed to replicate the freeze-thaw stresses experienced during manufacturing, using computational fluid dynamics to calculate the necessary conditions for small containers. With our approach, we are able to achieve the same decay of quality attributes observed during the freeze-thaw cycles on a manufacturing scale, using only 100 mL of material. This enables you to conduct experiments and tests more efficiently and cost-effectively, without sacrificing accuracy or reliability.

normablast multiple bottles

LARGE-SCALE FOR MULTIPLE Containers

Smartfreez’s NORMABLAST system can handle multiple bottles or bags. Its scalable design makes it a versatile and customizable solution for freeze-thaw processes. Its consistency in performance, regardless of the number of containers in the process, ensures a reliable and high-quality result.

CFD simulations for Freeze-thaw

NORMABLAST PILOT AND NORMABLAST LAB

The NORMABLAST Pilot and NORMABLAST Lab are compact versions of the NORMABLAST system. The NORMABLAST Pilot is ideal for conducting experiments "at scale" or for producing early development batches. Additionally, the system is compatible with scale-down devices, making it a versatile tool for a variety of applications. The NORMABLAST Lab is a portable version of the NORMABLAST Pilot that can be adapted to your existing freezing or thawing equipment. This allows you to transform a conventional freezer/thawer into a high-performance system with minimal effort.

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