| Lab Instruments

DESIGN PRINCIPLE

Imposing Isochoric conditions with stainless-steel vials limits volume expansion, preventing the ice growth. This enables to run isothermal stability studies below 0 ºC, without freezing the samples.

FORMULATE WITH COLD

Measure directly the influence of cryopreservatives at low temperatures, avoiding the uncertainty of predictions made by modelling high temperature data.

ACCELERATED STABILITY

Anticipate cold stability in a few days (by approaching cold denaturation temperature) and develop accurate degradation models for broad temperature ranges.

KEY SPECIFICATIONS

Capacity: 12 cassettes each with 3 wells of 400 μl Dimensions (mm): 460 (d) x 360 (w) x 600 (h) Temperature range: -25 ºC to 25 ºC Weight (kg): 40 Patent pending.

DESIGN PRINCIPLE

The time within ice while above glass transition correlates directly with protein degradation. The distribution of this stress-time across a container can be obtained by a CFD simulation, and imposed in a 5 mL vial, by accurate ice-nucleation and control of heat flow.

LOW-VOLUME SCALE-DOWN

Run freeze-thaw cycles at an early stage, with only 5 mL, in conditions that are representative of installed manufacturing processes (bottles or bags).

AUGMENTED DIGITAL TWIN*

Design your own methods for cryopreservation of biological products, or analytical samples, with high consistency and reproducibility. Use the Digital Twin (CFD simulation) to understand the impact of your method on sensitive substances.

*Digital Twin is available as simulation services.

KEY SPECIFICATIONS

Capacity: 1 holder for 6 10 mL vials (5 mL of fill volume) Dimensions (mm): 460 (d) x 360 (w) x 600 (h) Temperature range: -85 ºC to 25 ºC Weight (kg): 40

Patent pending

SMARTFREEZ CRYO CELL

Design your own methods for cryopreservation with high consistency and reproducibility. Use the Digital Twin (CFD simulation) to understand the impact of your parameters on key stresses for cells viability.

DESIGN PRINCIPLE

A unidirectional heat-transfer geometry limits natural convection, enabling precise control of ice-nucleation and crystal growth (velocity and direction).

REACH HIGHER VIABILITY

The thermal stress to cells is minimized by preventing supercooling, only a “sacrificial layer” of the liquid (5% volume) supercools to induce controlled ice-nucleation. Bottom-up ice-growth is promoted to prevent mechanical stresses caused by pressure.

AUGMENTED DIGITAL TWIN*

Design your own methods for cryopreservation with high consistency and reproducibility. Use the Digital Twin (CFD simulation) to understand the impact of your parameters on key stresses for cells viability.

*Digital Twin is available as simulation services.

KEY SPECIFICATIONS

Capacity: 1 holder for 48 2 mL vials Dimensions (mm): 460 (d) x 360 (w) x 600 (h) Temperature range: -85 ºC to 25 ºC Weight (kg): 40

Patent pending