Lab Instruments

COLD STABILITY
ACCELERATOR

Cold Stability Accelerator equipment
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Design principle

Imposing Isochoric conditions with stainless-steel vials, limits volume expansion, preventing the ice growth. Consequently, this enables to run isothermal stability studies below 0 ºC, without freezing the samples.

Formulate with Cold

Measures directly the influence of cryopreservatives at low temperatures, avoiding the uncertainty of predictions made from high temperature modelling data.

Accelerated Stability

Anticipates cold stability in a few days (by approaching cold denaturation temperature), also develops accurate degradation models for broad temperature ranges.

Key Specifications

Capacity: 12 cassettes each with 3 wells of 400 μlDimensions (mm): 460 (d) x 360 (w) x 600 (h)Temperature range: -25 ºC to 25 ºCWeight (kg): 40Patent pending.

MICRO
SCALE-DOWN

Micro Scale-Down equipment
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Design Principle

When above glass transition, the time within ice while correlates directly with protein degradation. Additionally, the distribution of this stress-time across a container can be obtained by a CFD simulation, and furthermore imposed in a vial containing less than 10 mL, by accurate ice-nucleation and also control of heat flow.

Low-Volume Scale-Down

Runs freeze-thaw cycles at an early stage, with less than 10 mL, in conditions that are representative of installed manufacturing processes (bottles or bags).

Augmented Digital Twin*

Design your own methods for cryopreservation of biological products, or analytical samples, with high consistency and reproducibility. Also, use the Digital Twin (CFD simulation) to understand the impact of your method on sensitive substances.

* Digital Twin is available as simulation services.Al

Key Specifications

Capacity: 1 holder for 6 x 10 mL vials (5 mL of fill volume)Dimensions (mm): 460 (d) x 360 (w) x 600 (h)Temperature range: -85 ºC to 25 ºCWeight (kg): 40Patent pending

CELL

CRYOCELL equipment for cryopreservation
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Design Principle

A unidirectional heat-transfer geometry limits natural convection, enabling precise control of ice-nucleation and crystal growth (velocity and direction).

Reach Higher Viability

The thermal stress to cells is minimized by preventing supercooling, only a “sacrificial layer” of the liquid (5% volume) supercools to induce controlled ice-nucleation. Bottom-up ice-growth is promoted to prevent mechanical stresses caused by pressure.

Augmented Digital Twin*

Design your own methods for cryopreservation with high consistency and reproducibility. Use the Digital Twin (CFD simulation) to understand the impact of your parameters on key stresses for cells viability.

* Digital Twin is available as simulation services.

Key Specifications

Capacity: 1 holder for 48 x 2 mL vialsDimensions (mm): 460 (d) x 360 (w) x 600 (h)Temperature range: -85 ºC to 25 ºCWeight (kg): 40Patent pending

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