Low sample volume
The MSD mimics manufacturing stresses in just 5 mL sample volume..

The Micro Scale-Down (MSD) is a precise rate-freezer and rate-thawer that replicates the stresses of large-scale bio-manufactuing.
This is a small-volume physical model designed to assist freeze-thaw formulation and process design.
Featured in the following papers:
Our MSD is designed to be compatible with most containers on the market, such as:
The MSD mimics manufacturing stresses in just 5 mL sample volume..
Scale down methods validated and documented through CFD simulations.
The MSD can replicate, at small scale, bags, bottles, steel vessels, and much more.
Full Method Customization
Custom recipes of up to 16 steps can be set to run automatically with MSD.
Data Export
Export all your data for a deep dive into experiments’ outcomes.
Data Visualization
MSD is prepared for data overview on the go.
Touch Display
Quick and easy to use.
Digital Twin Compatibility
Custom recipes can be translated into Digital Twins and vice-versa.
Capacity
1 holder for 6 x 10 mL vials (5 mL of fill volume)
Dimensions (mm)
460 (d) x 360 (w) x 600 (h)
Temperature range
-90 ºC to 30 ºC
Weight (kg)
40
Patent status
Patented
Deciphering protein aggregation in freeze-thaw process: the roles of cold denaturation and shear stress
Co-Authored with: IST-Universidade de Lisboa, Boehringer Ingelheim Pharma