Low sample volume
The MSD mimics manufacturing stresses in just 5 mL sample volume..

The Micro Scale-Down (MSD) is a precise rate-freezer and rate-thawer that replicates the stresses of large-scale bio-manufacturing.
This is a small-volume physical model designed to assist freeze-thaw formulation and process design.
Featured in the following papers:
Our MSD is designed to be compatible with most containers on the market, such as:
The MSD mimics manufacturing stresses in just 5 mL sample volume..
Scale down methods validated and documented through CFD simulations.
The MSD can replicate, at small scale, bags, bottles, steel vessels, and much more.
Full Method Customization
Custom recipes of up to 16 steps can be set to run automatically with MSD.
Data Export
Export all your data for a deep dive into experiments’ outcomes.
Data Visualization
MSD is prepared for data overview on the go.
Touch Display
Quick and easy to use.
Digital Twin Compatibility
Custom recipes can be translated into Digital Twins and vice-versa.
Capacity
1 holder for 6 x 10 mL vials (5 mL of fill volume)
Dimensions (mm)
460 (d) x 360 (w) x 600 (h)
Temperature range
-90 ºC to 30 ºC
Weight (kg)
40
Patent status
Patented
Service
Best if you need the results without owning the hardware.
Results without the hardware investment
Describe your needs and we develop the formulations with our equipment.
Tailored to your needs
Tell us about where your project stands and what you want to achieve. We develop from there.
No lab setup needed
You don't need to run or maintain anything.
Validate before you invest
Prove the approach works on your samples before commiting.
Rent Equipment
Best if you need hands-on access for a defined period of time.
Equipment on your timeline
Bring the device in for the exact time window your project needs.
Test it against your real process
See how it performs in your workflow before you commit.
Low commitment
Get started without a full on purchase or long approval cycle.
Run your own experiments
Get full control of your experiments. Your samples, data, and IP never leave your lab.
Buy Device
Best if you'll use the device long-term and want full control.
End to end support
Full onboarding, training, and scheduled maintenances.
Unlimited use
No time windows, no per-project fees. Run as many experiments as you need.
Data and IP stays 100% in-house
All your data stays in-house, giving you complete confidentiality and control.
Warranty protected
Covered against defects and issues.
Hybrid (Buy + Service)
Best if you want complete ownership plus and expert partner.
Own the device, plus the expertise behind it
Get full control over the device and access to our specialized cryopreservation know-how.
Support across the entire process
We're here to help you throughout the entire journey, from setup to scale-up.
Experiment freely, with a safety net
Run your own experiments, and lean on our scientists whenever you hit a roadblock.
Skip the trial-and-error
Start from proven formulations instead of burning time and samples on optimization.
End to end support
Full onboarding, training, and scheduled maintenances.
Deciphering protein aggregation in freeze-thaw process: the roles of cold denaturation and shear stress
Co-Authored with: IST-Universidade de Lisboa, Boehringer Ingelheim Pharma