Cold Stability Accelerator (CSA)

The Cold Stability Accelerator (CSA) measures directly the influence of cryopreservatives at low temperatures, avoiding the uncertainty of predictions made from high temperature modelling data.

Imposing isochoric conditions with stainless-steel vials, limits volume expansion, preventing the ice growth. This enables to run isothermal stability studies below 0 ºC, without freezing the samples.

Featured in the following papers:

Native and Non-Native aggregation pathways of antibodies anticipated by cold-accelerated studies

Co-Authored with: IST-Universidade de Lisboa, Sanofi

Connecting high-temperature and low-temperature protein stability and aggregation

Co-Authored with: IST-Universidade de Lisboa, University of Delaware

Parallel chromatography and in situ scattering to interrogate competing protein aggregation pathways

Co-Authored with: IST-Universidade de Lisboa, University of Delaware

Stability of Protein Formulations at Subzero Temperatures by Isochoric Cooling

Co-Authored with: Universidade do Algarve, IST-Universidade de Lisboa

About the CSA

Specs

What can the Cold Stability Accelerator (CSA) do for you?

Accelerated cold-stress assessment

Assess the influence of cold-stress on your formulations in days, not months.

Subzero testing

Rapid isothermal studies at below 0ºC.

Predictive stability modelling

The CSA facilitates the development of accurate degradation models to predict in a few days the long term stability of proteins.

Direct stability information

The CSA studies samples at the exact conditions of cold storage, eliminating the uncertainty of high-temperature modelling. What you get is stability data that is real, direct, interpretable, and actionable.

A scientific breakthrough

Data Export

Export all your data for a deep dive into experiments’ outcomes.

Data Visualization

CSA is prepared for data overview on the go.

Touch Display

Quick and easy to use.

Specifications

Capacity

12 cassettes each with 3 wells of 400 μl

Dimensions (mm)

460 (d) x 360 (w) x 600 (h)

Temperature range

-25 ºC to 25 ºC

Weight (kg)

Patent status

Patented