Scale-Down Devices (SDD)

Frontal view picture of SmartFreez's Scale-Down Devices (SDD).

The SDD is a stand-alone system designed to replicate large-scale freeze-thaw stresses in just 100 mL.

The Scale-Down Devices (SDDs) are insulating shells made to replicate at a smaller scale (100mL) the freeze-thaw stresses of large bottles or bags experienced during manufacturing.

The SDD is also available for bags.

Featured in the following papers:

Evaluation of Two Novel Scale-Down Devices for Testing Monoclonal Antibody Aggregation During Large-Scale Freezing

Co-Authored with: LMU München, IST-Universidade de Lisboa, Novartis, Sandoz GmbH

Cryoconcentration and 3D Temperature Profiles During Freezing of mAb Solutions in Large-Scale PET Bottles and a Novel Scale-Down Device

Co-Authored with: IST-Universidade de Lisboa, LMU München, Novartis, Sandoz GmbH

A New Perspective on Scale-Down Strategies for Freezing of Biopharmaceutics by Means of Computational Fluid Dynamics

Co-Authored with: IST-Universidade de Lisboa, AstraZeneca
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Frontal view picture of SmartFreez's Scale-Down Devices (SDD).

About the SDD

What can the SDD do for you?

Flexible and Adaptable - The SDD replicate stresses of bottles of up to 20 L in just 100 mL.
Resource Efficient - Replicate large-scale (up to 20 L) freeze-thaw stresses in just 100 mL.
Digitally Validated - Simulation methods are validated with the SDD.
Physics Driven Reliability - Computational Fluid Dynamics (CFD) is used to map the freeze-thaw stresses of large containers.

A scientific breakthrough

Compact 

The SDDs are designed to fit and make use of a 100 mL bottle.

Customizable Design

SDDs can be customizable based on each customer’s specific requirements.

Easy to Use

Preparing the SDD is an easy 5 step process. Using it is even easier!

Validation Setup

The SDD comes with a complete validation kit to facilitate qualification purposes.

Additional information

 Patent status

Patented

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